SynDIG1 regulation of synaptic AMPA receptor targeting
نویسندگان
چکیده
منابع مشابه
SynDIG1 Promotes Excitatory Synaptogenesis Independent of AMPA Receptor Trafficking and Biophysical Regulation
AMPA receptors-mediators of fast, excitatory transmission and synaptic plasticity in the brain-achieve great functional diversity through interaction with different auxiliary subunits, which alter both the trafficking and biophysical properties of these receptors. In the past several years an abundance of new AMPA receptor auxiliary subunits have been identified, adding astounding variety to th...
متن کاملRegulation of AMPA receptor trafficking and synaptic plasticity.
AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the tightly regulated trafficking of AMPARs into and out of synapses. The life cy...
متن کاملAMPA receptor regulation during synaptic plasticity in hippocampus and neocortex.
Discovery of long-term potentiation (LTP) in the dentate gyrus of the rabbit hippocampus by Bliss and Lømo opened up a whole new field to study activity-dependent long-term synaptic modifications in the brain. Since then hippocampal synapses have been a key model system to study the mechanisms of different forms of synaptic plasticity. At least for the postsynaptic forms of LTP and long-term de...
متن کاملLipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.
The targeting and surface expression of membrane proteins are critical to their functions. In neurons, synaptic targeting and surface expression of AMPA-type glutamate receptors were found to be critical for synaptic plasticity such as long-term potentiation and long-term depression (LTD). PICK1 (protein interacting with C kinase 1) is a cytosolic protein that interacts with many membrane prote...
متن کاملAmpa Receptor and Synaptic Plasticity
Title of Document: AMPA RECEPTOR AND SYNAPTIC PLASTICITY
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ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2010
ISSN: 1942-0889
DOI: 10.4161/cib.3.4.11765